منابع مشابه
P-gp and taxanes
In the past years, the development of oral formulations of the taxane anticancer drugs paclitaxel (Taxol ®) and docetaxel (Taxotere ®) has been the focus of preclinical and clinical research in our groups. A major limitation in the concept of oral administration of paclitaxel and docetaxel is their low oral availability [1]. Paclitaxel and docetaxel have poor aqueous solubility and upon oral ad...
متن کاملPotential roles of P-gp and calcium channels in loperamide and diphenoxylate transport.
This study examined the accumulation and transport of two related systemic opioids used as antidiarrhoeal drugs and compared their rates of transport with known P-glycoprotein (P-gp) substrates used in our in vitro environment. Cellular uptake and efflux and transcellular transport were all determined using Caco-2 cells after exposure to loperamide or diphenoxylate, with or without a range of e...
متن کاملPotent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.
Compounds 8a-d have been designed as bioisosters of tariquidar for imaging P-gp expression and density by PET. The results displayed that compounds 8b and 8d could be considered potential P-gp/BCRP ligands suitable as (11)C and (18)F radiotracers, respectively.
متن کامل‘Et tu, inhibitor?’: the potential for HIV inhibitors to prime P-gp-mediated chemoresistance in cancer
“Thus, by coalescing the established information of P-gp-driven MDR in cancer and recent reports demonstrating the ability of nonchemotherapeutic inhibitors of HIV to increase P-gp activity in both cancerous and noncancerous tissue, future direction should be considered in determining which commonly administered drug regimens have the potential to prime cancer-susceptible tissues to be more res...
متن کاملMini-P-gp and P-gp Co-Expression in Brown Trout Erythrocytes: A Prospective Blood Biomarker of Aquatic Pollution.
In aquatic organisms, such as fish, blood is continually exposed to aquatic contaminants. Multidrug Resistance (MDR) proteins are ubiquitous detoxification membrane pumps, which recognize various xenobiotics. Moreover, their expression is induced by a large class of drugs and pollutants. We have highlighted the co-expression of a mini P-gp of 75 kDa and a P-gp of 140 kDa in the primary culture ...
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ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2010
ISSN: 0036-8709,2218-0532
DOI: 10.3797/scipharm.cespt.8.pot11